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KMID : 0370220010450060683
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Yakhak Hoeji
2001 Volume.45 No. 6 p.683 ~ p.693
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Renal Action of Raclopride, a Dopamine D₂ Receptor Antagonist, in Dogs
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고석태/Ko ST
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Abstract
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This study was attempted to investigate the effect of raclopride, a dopamine D₂ receptor antagonist, on renal function in dog. Raclopride (70~220㎍/kg), when given intravenously; produced antidiuresis along with the decrease in free water clearance (C_H2O), urinary excretion of sodium and potassium (E_Na, E_K), partially decreased osmolar clearance (C_osm) and increased reabsorption rates of sodium and potassium in renal tubules (R_Na, R_K). Raclopride administered into a renal artery did not inf1uence on renal function in small doses (10 and 30㎍/kg), whereas exhibited the decrease of urine volume (Vol) and C_H2O both in experimental and control kidney in much dose (100㎍/kg), at this time, the decreased rates of both Vol. and C_H2O were more prominent in control kidney rather than that elicited in experimental kidney, and then only E_Na was decreased in control kidney, but increased in experimental kidney. Raclopride administered via carotid artery (30~200㎍/kg) did not influence at all on renal function. Antidiuretic action induced by raclopride given intravenously was not affected by renal denervation. Raclopride given into carotid artery was little effect on renal function without relation to renal denervation. Above results suggest that raclopride produces antidiuresis by potentiation of antidiuretic hormone (ADH) action in blood without increase of ADH secretion in posterior pituitary gland, it is not related to renal nerve function in dogs.
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KEYWORD
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